Mopreme's first recorded appearance, under the alias Mocedes, was on Tony Toni Toné's hit single "Feels Good" in the year 1990. His first collaboration with his brother was on the single and video "Papaz Song", from the 1993 album Strictly 4 My N.I.G.G.A.Z. under the name 'Wycked'. In 1993 Mopreme and his brother Tupac formed the group Thug Life with friends Big Syke, Macadoshis and Rated R. On September 26, 1994, the group released the only Album Thug Life: Volume 1 which went Gold. Mopreme has been credited as a Writer for many significant tracks on this album. He was an original member of both his Thug Life group, as well as a premier member of Outlawz. Mopreme, as well as Big Syke dropped out of the group, but contrary to rumors, was never signed to Death Row Records.
In 2002, he was interviewed in the documentary Biggie & Tupac.
In June 2008, Mopreme revealed that he had signed on as a consulting Producer for the BET series, American Gangster, titled "Mutulu Shakur and The Republic of New Afrika." The show will feature his incarcerated father, Mutulu Shakur, a proponent of the Republic of New Afrika in the 1960s and '70s and member of the neo-Marxist/black nationalist group Black Liberation Army. Mopreme provided insight, direction, subject matter for interviews, and acted as a liaison between the show and his father.