After leaving Oxford early, before completing her degree, Sharrock took the Directors course at the Royal National Theatre, and worked as an assistant Director on a number of productions at London Theatres and on tour. In the summer of 2000, she won the James Menzies Kitchin Trust Award (JMK Trust Award), which allowed her to mount a production of Top Girls at the Battersea Arts Centre. The show was a success and toured the UK twice, before a brief run at a West End theatre.
She began her three-year tenure at the Southwark Playhouse in January 2001. In addition to work at the Playhouse, she served as an associate Director on the long-running West End production of 'Art', directed works for the Royal National Theatre and English Touring Theatre, and began her association with the Peter Hall Company. Sharrock left the Southwark Playhouse in late 2003, and became artistic Director at the Gate Theatre in August 2004. She left this post in 2006, and had been widely tipped to take over at the Royal Court Theatre[2], although the post eventually went to Dominic Cooke. She served on the selection panel for the 2005 Linbury Biennial Prize for Stage Design, and is now a JMK Award trustee.
Her production of Cloud Nine played at the Almeida Theatre from 31 October to 8 December 2007. In 2008, she directed Happy Now? at the National Theatre, before taking her 2007 West End revival of Equus to New York in 2008 with Daniel Radcliffe making his Broadway debut. In 2009, she directed a production of As You Like It at Shakespeare's Globe.
In 2010, Sharrock directed a revival of Martin Crimp's version of The Misanthrope originally by Moliere, at the Comedy Theatre starring Keira Knightley and Damian Lewis. Also in 2010, she directed Benedict Cumberbatch in the Olivier-winning revival of After the Dance by Terence Rattigan.
In 2012, she directed Tom Hiddleston in Henry V as part of the BBC's miniseries The Hollow Crown.
Sharrock's feature film debut, an adaptation of the novel Me Before You, was announced in 2014. The film was released in 2016 and grossed $207 million worldwide.
