He attended Unionville High School, and was later accepted into the National Theatre School of Canada, graduating in 1998.
On stage, he appeared as the titular character in Léo by Rosa Labordé at the Tarragon Theatre during the winter of 2006. He reprised the role in 2007, and toured Canada with the production in winter 2008. He played one of the lead roles in the psychological thriller Sam's Lake. Other recent films include Cursing Hanley, The Gospel of John, and Looking for Angelina.
As a Playwright, Salvatore was named a finalist for the 2007 Governor General's Award for English drama, for his debut work In Gabriel's Kitchen. The play was originally produced at Buddies in Bad Times Theatre in March 2006, where it proved a box-office success. The play went on to be translated into Italian, and was performed in October 2006, at Teatro Della Limonaia, in Florence, Italy. The script was published in May 2007, by Playwrights Canada Press.
In Gabriel's Kitchen premiered in the US in January 2008, at The New Conservatory Theatre Center in San Francisco, and was subsequently produced in New York. Antonio is currently writing for Tarragon Theatre, Factory Theatre and Buddies in Bad Times Theatre. He was the playwright-in-residence at Buddies in Bad Times for its 2004-2005 season.
As of June 7, 2012 he can be seen on the new supernatural medical drama Saving Hope as Victor Reis. In 2014 he appeared in the sitcom 24 Hour Rental.
In 2013, Antonio presented Truth/Dare: A Satire (With Dance), an interactive audience participation show which featured staged reenactments of scenes from Madonna's 1991 film Truth or Dare, at Buddies in Bad Times during Toronto's Pride Week. The show's cast also included Adamo Ruggiero, Gavin Crawford and Keith Cole.