As per our current Database, Robert Bruce Merrifield has been died on May 14, 2006(2006-05-14) (aged 84)\nCresskill, New Jersey.
When Robert Bruce Merrifield die, Robert Bruce Merrifield was 84 years old.
|Popular As||Robert Bruce Merrifield|
|Age||84 years old|
|Born||July 15, 1921 (Fort Worth, Texas, United States)|
|Town/City||Fort Worth, Texas, United States|
Robert Bruce Merrifield’s zodiac sign is Leo. According to astrologers, people born under the sign of Leo are natural born leaders. They are dramatic, creative, self-confident, dominant and extremely difficult to resist, able to achieve anything they want to in any area of life they commit to. There is a specific strength to a Leo and their "king of the jungle" status. Leo often has many friends for they are generous and loyal. Self-confident and attractive, this is a Sun sign capable of uniting different groups of people and leading them as one towards a shared cause, and their healthy sense of humor makes collaboration with other people even easier.
Robert Bruce Merrifield was born in the Year of the Rooster. Those born under the Chinese Zodiac sign of the Rooster are practical, resourceful, observant, analytical, straightforward, trusting, honest, perfectionists, neat and conservative. Compatible with Ox or Snake.
He was born in Fort Worth, Texas, on 15 July 1921, the only son of George E. Merrifield and Lorene née Lucas. In 1923 the family moved to California where he attended nine grade schools and two high schools before graduating from Montebello High School in 1939. It was there that he developed an interest both in chemistry and in astronomy.
He returned to graduate school at the UCLA chemistry department with professor of biochemistry M.S. Dunn to develop microbiological methods for the quantitation of the pyrimidines. The day after graduating on 19 June 1949, he married Elizabeth Furlong and the next day left for New York City and the Rockefeller Institute for Medical Research.
At the Institute, later Rockefeller University, he worked as an Assistant for Dr. D.W. Woolley on a dinucleotide growth factor he discovered in graduate school and on peptide growth factors that Woolley had discovered earlier. These studies led to the need for peptide synthesis and, eventually, to the idea for solid phase peptide synthesis (SPPS) in 1959. In 1963, he was sole author of a classic paper in the Journal of the American Chemical Society in which he reported a method he called "solid phase peptide synthesis". This article is the fifth most cited paper in the journal's history.
In the mid-60s Dr. Merrifield's laboratory first synthesized bradykinin, angiotensin, desamino-oxytocin and insulin. In 1969, he and his colleague Bernd Gutte announced the first synthesis of the enzyme, ribonuclease A. This work proved the chemical nature of enzymes.
Dr. Merrifield's method greatly stimulated progress in biochemistry, pharmacology and Medicine, making possible the systematic exploration of the structural basis of the activities of enzymes, hormones and antibodies. The development and applications of the technique continued to occupy his laboratory, where he remained active at the bench until recently. In 1993, he published his autobiography, "Life during a Golden Age of Peptide Chemistry." He received the Association of Biomolecular Resource Facilities Award for outstanding contributions to Biomolecular Technologies in 1998.
After a long illness R. Bruce Merrifield died on May 14, 2006 at the age of 84 in his home in Cresskill, New Jersey. He is survived by his wife, children and 16 grandchildren.