As per our current Database, Martin Rodbell has been died on December 7, 1998(1998-12-07) (aged 73)\nChapel Hill, North Carolina, U.S..
When Martin Rodbell die, Martin Rodbell was 73 years old.
|Popular As||Martin Rodbell|
|Age||73 years old|
|Born||December 01, 1925 (Baltimore, Maryland, U.S., United States)|
|Town/City||Baltimore, Maryland, U.S., United States|
Martin Rodbell’s zodiac sign is Capricorn. According to astrologers, Capricorn is a sign that represents time and responsibility, and its representatives are traditional and often very serious by nature. These individuals possess an inner state of independence that enables significant progress both in their personal and professional lives. They are masters of self-control and have the ability to lead the way, make solid and realistic plans, and manage many people who work for them at any time. They will learn from their mistakes and get to the top based solely on their experience and expertise.
Martin Rodbell was born in the Year of the Ox. Another of the powerful Chinese Zodiac signs, the Ox is steadfast, solid, a goal-oriented leader, detail-oriented, hard-working, stubborn, serious and introverted but can feel lonely and insecure. Takes comfort in friends and family and is a reliable, protective and strong companion. Compatible with Snake or Rooster.
Rodbell was born in Baltimore, Maryland, the son of Shirley (née Abrams) and Milton Rodbell, a grocer. His family was Jewish. After graduating from the Baltimore City College high school, he entered Johns Hopkins University in 1943, with interests in biology and French existential literature. In 1944, his studies were interrupted by his military Service as a U.S. Navy radio operator during World War II. He returned to Hopkins in 1946 and received his B.S. in biology in 1949. In 1950, he married Barbara Charlotte Ledermann, a former friend of the legendary diarist Anne Frank, with whom he had four children. Rodbell received his Ph.D. in biochemistry at the University of Washington in 1954. He did post-doctoral work at the University of Illinois at Urbana-Champaign from 1954 to 1956. In 1956, Rodbell accepted a position as a research biochemist at the National Heart Institute, part of the National Institutes of Health, in Bethesda, Maryland. In 1985, Rodbell became Scientific Director of the NIH's National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina where he worked until his retirement in 1994. He was also Adjunct Professor of Cell Biology at Duke University (from 1991 to 1998) and Adjunct Professor of Pharmacology at the University of North Carolina at Chapel Hill. He died in Chapel Hill of multiple organ failure after an extended illness.
Reflecting the increasingly Common analogies between computer science and biology in the 1960s, Rodbell believed that the fundamental information processing systems of both computers and biological organisms were similar. He asserted that individual cells were analogous to cybernetic systems made up of three distinct molecular components: discriminators, transducers, and amplifiers (otherwise known as effectors). The discriminator, or cell receptor, receives information from outside the cell; a cell transducer processes this information across the cell membrane; and the amplifier intensifies these signals to initiate reactions within the cell or to transmit information to other cells.
In December 1969 and early January 1970, Rodbell was working with a laboratory team that studied the effect of the hormone glucagon on a rat liver membrane receptor—the cellular discriminator that receives outside signals. Rodbell discovered that ATP (adenosine triphosphate) could reverse the binding action of glucagon to the cell receptor and thus dissociate the glucagon from the cell altogether. He then noted that traces of GTP (guanosine triphosphate) could reverse the binding process almost one thousand times faster than ATP. Rodbell deduced that GTP was probably the active biological factor in dissociating glucagon from the cell's receptor, and that GTP had been present as an impurity in his earlier experiments with ATP. This GTP, he found, stimulated the activity in the guanine nucleotide protein (later called the G-protein), which, in turn, produced profound metabolic effects in the cell. This activation of the G-protein, Rodbell postulated, was the "second messenger" process that Earl W. Sutherland had theorized. In the language of signal transduction, the G-protein, activated by GTP, was the principal component of the transducer, which was the crucial link between the discriminator and the amplifier. Later, Rodbell postulated, and then provided evidence for, additional G-proteins at the cell receptor that could inhibit and activate transduction, often at the same time. In other words, cellular receptors were sophisticated enough to have several different processes going on simultaneously.
The laugh is on those who, burdened with pretensions of truth, believe they can fathom within 15 minutes of human existence what has transpired over eons of space and time in this Universe . So, I extol the intuitions encapsulated in the folds of my mind from whence occasionally they hurtle to the forebrain and in a twinkling of a proton’s discharge bring to fruition a thought, an idea borne on the feathery appendages of teeming neurons wedded in a seamless synergy. Those fleeting moments are cherished as are those precious impulses imparted by the innumerable individuals who nurtured and instilled unknowingly their encrypted thoughts in mine.