Edwin G. Krebs

About Edwin G. Krebs

Who is it?: Biochemist
Birth Day: June 06, 1918
Birth Place: Lansing, Iowa, United States, United States
Alma mater: University of Illinois at Urbana-Champaign (B.S.), Washington University in St. Louis (M.D.)
Awards: Louisa Gross Horwitz Prize (1989) Welch Award in Chemistry (1991) Nobel Prize in Physiology or Medicine (1992)
Fields: biochemistry
Institutions: University of Washington, Seattle University of California, Davis

Edwin G. Krebs

Edwin G. Krebs was born on June 06, 1918 in Lansing, Iowa, United States, United States, is Biochemist. Edwin G. Krebs was a noted American biochemist, who, along with Edmond H. Fischer, won the 1992 Nobel Prize in Physiology or Medicine. Krebs lost his father when he was only fifteen years old and the incident had a sad repercussion on his otherwise happy childhood. He started thinking what to do with his life even when he was a high school student. Ultimately, he entered the Washington University School of Medicine and earned his medical degrees at the age of twenty five. After a short military service, he was drawn to basic research and joined University of Washington, Seattle as an Assistant Professor at the Department of Biochemistry. There with Edmond H. Fischer, he began to work on enzymology of phosphorylase and within a short time, discovered a biochemical process called reversible protein phosphorylation, which earned them the coveted Nobel Prize many years later. Later, they worked separately on different aspect of the process. He was blessed with a keen intellect. His amazing research output earned him an iconic status among his the scientific fraternity. He was also a loving mentor to numerous students and postdoctoral fellows. Many of them still remember him as a kind and gentle mentor.
Edwin G. Krebs is a member of Scientists

Does Edwin G. Krebs Dead or Alive?

As per our current Database, Edwin G. Krebs has been died on December 21, 2009(2009-12-21) (aged 91)\nSeattle, Washington.

🎂 Edwin G. Krebs - Age, Bio, Faces and Birthday

When Edwin G. Krebs die, Edwin G. Krebs was 91 years old.

Popular As Edwin G. Krebs
Occupation Scientists
Age 91 years old
Zodiac Sign Cancer
Born June 06, 1918 (Lansing, Iowa, United States, United States)
Birthday June 06
Town/City Lansing, Iowa, United States, United States
Nationality United States

🌙 Zodiac

Edwin G. Krebs’s zodiac sign is Cancer. According to astrologers, the sign of Cancer belongs to the element of Water, just like Scorpio and Pisces. Guided by emotion and their heart, they could have a hard time blending into the world around them. Being ruled by the Moon, phases of the lunar cycle deepen their internal mysteries and create fleeting emotional patterns that are beyond their control. As children, they don't have enough coping and defensive mechanisms for the outer world, and have to be approached with care and understanding, for that is what they give in return.

🌙 Chinese Zodiac Signs

Edwin G. Krebs was born in the Year of the Horse. Those born under the Chinese Zodiac sign of the Horse love to roam free. They’re energetic, self-reliant, money-wise, and they enjoy traveling, love and intimacy. They’re great at seducing, sharp-witted, impatient and sometimes seen as a drifter. Compatible with Dog or Tiger.

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Edwin Krebs is not to be confused with Hans Adolf Krebs (1900–1981), who was also a Nobel Prize–winning biochemist and who discovered the citric acid cycle, which is also known as the Krebs cycle.


Krebs was born in Lansing, Iowa, the third child of william Carl Krebs, a Presbyterian minister and Louise Helen (Stegeman) Krebs. The family moved frequently due to the nature of his father's work, though they settled in Greenville, Illinois when Krebs was six and remained there until his father's unexpected death in 1933. Louise Krebs decided to move her family to Urbana, Illinois, where Krebs's elder brothers were attending the University of Illinois at Urbana-Champaign. Krebs attended Urbana High School, and enrolled at the University of Illinois at Urbana-Champaign in 1936. In his fourth year of study Krebs had decided to either pursue a higher degree in organic chemistry or study Medicine. Receiving a scholarship to attend Washington University School of Medicine in St. Louis, he chose the latter.


The School of Medicine afforded Krebs the opportunity to train as a physician as well as to gain experience in medical research. Following graduation in 1943, he undertook an 18-month residency at Barnes Hospital in St. Louis and then went on active duty as a medical officer in the Navy. Krebs was discharged from the Navy in 1946 and was unable to immediately return to hospital work; he was advised to study basic science instead. He chose to study biochemistry and was postdoctoral fellow to Carl and Gerty Cori, working on the interaction of protamine with rabbit muscle phosphorylase. At the completion of his two years' study, Krebs decided to continue his career as a biochemist.


In 1948 Krebs accepted a position as assistant professor of biochemistry at the University of Washington, Seattle. When Edmond H. Fischer arrived at the Department in 1953, the pair decided to work on the enzymology of phosphorylase. During the course of their study they were able to observe the mechanism by which interconversion of the two forms of phosphorylase takes place: reversible protein phosphorylation.


Krebs's interest in teaching and administration led him to leave the University of Washington to become the founding chairman of the Department of Biochemistry at the University of California, Davis. In 1977 he returned to the University of Washington as Chairman of the Department of Pharmacology.


Explained simply, in reversible protein phosphorylation a protein kinase takes a phosphate group from adenosine triphosphate (ATP) and attaches it to a specific site on a protein, introducing both extra mass and negative charge at that site. This can alter the protein's shape and turn its function in a biological process up or down, either by changing its activity or its ability to bind to another protein. The protein can be converted back to its original state by a protein phosphatase that removes the phosphate. This cycle controls numerous metabolic processes, and plays a central role in the regulation of cell division, shape, and motility. Derangement of specific protein phosphorylation pathways is important in human disease, including cancer and diabetes. Fischer and Krebs were awarded the Nobel Prize for Physiology or Medicine in 1992 for the discovery of reversible protein phosphorylation, .


Krebs died on December 21, 2009. He is survived by his wife Virginia and three children.

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